Cerebrospinal fluid ratios with Aβ 42 predict preclinical brain β‐amyloid accumulation
نویسندگان
چکیده
منابع مشابه
Cerebrospinal fluid amyloid-β (Aβ) as an effect biomarker for brain Aβ lowering verified by quantitative preclinical analyses.
Reducing the generation of amyloid-β (Aβ) in the brain via inhibition of β-secretase or inhibition/modulation of γ-secretase has been pursued as a potential disease-modifying treatment for Alzheimer's disease. For the discovery and development of β-secretase inhibitors (BACEi), γ-secretase inhibitors (GSI), and γ-secretase modulators (GSM), Aβ in cerebrospinal fluid (CSF) has been presumed to b...
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BACKGROUND The cerebrospinal fluid (CSF) proteins beta-amyloid 42 (Abeta42) and Tau are believed to indirectly reflect some core pathological features of Alzheimer's disease (AD). Their topographic origin and their association with synaptic dysfunction are still not well understood. AIM The present study aimed to explore possible associations between cerebral glucose metabolism and CSF Abeta4...
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The reliability of cerebrospinal fluid (CSF)and CSF-amyloid assays for diagnosis of Alzheimer’s disease and other dementing disorders such as frontotemporal dementia (FTD), dementia with Lewy bodies (DLB) and Creutzfeldt–Jakob disease (CJD) is reviewed. CSF assessment of the two proteins is useful in early diagnosis of AD and to differentiate it from FTD and DLB. Extremely high CSFlevels can di...
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"The fixity of the internal environment is in short the condition of mental activity." Barcroft (1934), by this modification of Claude Bernard's famous aphorism, emphasized the necessity of maintaining the constancy of the composition of the brain to ensure its normal functioning. Among the mechanisms for ensuring this constancy are the blood-brain and blood-cerebrospinal fluid barriers. The te...
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Introduction: In some intoxicated patients, cerebrospinal fluid (CSF) is examined due to the prolonged loss of consciousness, focal neurologic findings, and fever of unknown origin. We aimed to evaluate the probable relationship between the different toxicity causes and the CSF indices in poisoned patients and determine if they could predict the patients’ outcome. Methods: All patients who h...
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ژورنال
عنوان ژورنال: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
سال: 2015
ISSN: 2352-8729,2352-8729
DOI: 10.1016/j.dadm.2015.11.006